This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical ventilation, through PKPD modelling.
Neonates < 45 weeks of corrected gestational age
Hospitalized in a Neonatal Intensive Care Unit
Undergoing mechanical ventilation
Patients that receive morphine alone or morphine and midazolam as continuous infusion
Current weight < 600g
Neonates under palliative care
Therapeutic hypothermia for perinatal anoxia
Neonates who underwent a surgical procedure during the past 72 hours