The purpose of this study is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple oral doses of HS-10522 in healthy Chinese participants and Chinese participants with mild hypertension.
Able to understand the procedures and methods of the study, willing to strictly adhere to the clinical trial protocol to complete the study, and voluntarily sign the Informed Consent Form (ICF).
Male or female participants aged 18 to 55 years (inclusive) at the time of signing ICF.
At screening, body weight ≥ 50 kg for males and ≥ 45 kg for females, with a body mass index (BMI) between 19.0 and 28.0 kg/m² (inclusive).
Abnormal vital signs, physical examination findings, or laboratory test results at screening that are deemed clinically significant by the investigator.
Presence of orthostatic hypotension or orthostatic tachycardia at screening.
Clinically significant abnormal findings on the 12-lead ECG at screening, as judged by the investigator.
Use of any medication within 2 weeks or 5 half-lives (whichever is longer) prior to screening, or anticipation of needing such medication during the trial.