A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShanghai Jiao Tong University School of Medicine

About this trial

The purpose of this study is to determine if the commonly administered chemotherapeutic agents including cisplatin, carboplatin, oxaliplatin, docetaxel and gemcitabine for solid tumors in clinical oncology, either a single format or given as combinations followed by surgery are effective in the treatment of relapsed and refractory non-small cell lung cancer patients.

Eligibility criteria

Qualifiers

Age ≤ 75 years with histologically proven NSCLC

No severe major organ dysfunction

WHO performance status of 0 or 1

No prior cancer chemotherapy

Disqualifiers

Age ≥ 76

Severe major organ dysfunction

WHO performance status of >1

Prior cancer chemotherapy

Trial design

Treatments tested in this trial

  • Cisplatin
  • Carboplatin
  • Docetaxel
  • Gemcitabine/Carboplatin
  • Gemcitabine/Cisplatin
  • Docetaxel/Oxaliplatin
  • Docetaxel/Carboplatin
  • Placebo

Treatment groups

500 Participants
are divided into 8 treatment groups

8

Treatment groups

See each treatment group below.

Sponsors and collaborators

Shanghai Jiao Tong University School of Medicine

Lead sponsor

Shanghai 10th People's Hospital

Collaborator

Jilin University

Collaborator

Jiangxi Provincial Cancer Hospital

Collaborator

Shanghai Tongji Hospital, Tongji University School of Medicine

Collaborator