About this trial
This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.
Eligibility criteria
Qualifiers
None
Disqualifiers
Sign and date the informed consent form (ICF), prior to the start of any study-specific qualification procedures.
Adults ≥18 years or the minimum legal adult age (whichever is greater) at the time the ICF is signed.
Has histologically or cytologically confirmed diagnosis of ES-SCLC who will require first-line (IL) therapy.
For Cohort 1, participant has received 4 cycles of 1L induction therapy with carboplatin, etoposide, and atezolizumab for ES-SCLC with ongoing CR PR, CR, or SD per RECIST v1.1 assessed by the investigator.
Trial design
Treatments tested in this trial
- Ifinatamab deruxtecan
- Atezolizumab
- Carboplatin
Treatment groups
7
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Daiichi Sankyo
Lead sponsor
Merck Sharp & Dohme LLC
Collaborator