Characterize the safety, tolerability and pharmacokinetics of ORX142 following single and multiple doses.
Healthy males or females as determined by assessments at the Screening Visit.
Presence of significant cardiac, pulmonary, gastrointestinal, hepatic, renal, hematological, malignancy, endocrine, neurological, or psychiatric disease, as determined by medical history, physical examination, and screening investigations.
History of seizure disorder, any other condition that increases the risk of seizure
Has a clinically significant sleep disorder, including insomnia or sleep apnea.