The purpose of this study is to find out whether the combination of mezigdomide and revumenib is a safe treatment for people with relapsed or refractory KMT2A-r, NUP98-r, and NPM1-m acute leukemias.
Participant must be ≥ 12 years of age at the time of signing the informed consent form (ICF).
Participant must weigh at least 40 kg
Participant is willing and able to adhere to the study visit schedule and other protocol requirements.
Participant has relapsed/refractory acute leukemia defined acute myeloid leukemia, acute lymphoblastic leukemia, or mixed phenotype acute leukemia after as failure of at least 1 prior line of therapy (can be either primary refractory disease or progression during or after treatment)
Participants with acute promyelocytic leukemia
Participants with isolated myeloid sarcoma
Participants who have previously received mezigdomide.
Participants with immediate life-threatening, severe complications of leukemia such as uncontrolled bleeding, pneumonia with hypoxia or shock, disseminated intravascular coagulation, or uncontrolled tumor lysis syndrome.