A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

About this trial

The purpose of this study is to establish a safe and tolerable dose of arlocabtagene autoleucel (BMS-986393) in combinations with alnuctamab, mezigdomide, iberdomide, and elranatamab in participants with relapsed and/or refractory multiple myeloma (RRMM).

Eligibility criteria

Qualifiers

History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2).

Measurable multiple myeloma (MM) as per International Myeloma Working Group (IMWG).

Eastern Cooperative Oncology Group performance status of 0-1.

Disqualifiers

Prior treatment with alnuctamab (Arm A), mezigdomide (Arm B), iberdomide (Arm C), elranatamab (Arm D) or BCMA-targeting therapy (Part 2 Arms A and D).

Prior treatment with GPRC5D-targeting therapies.

Other protocol-defined inclusion/exclusion criteria apply.

Trial design

Treatments tested in this trial

  • BMS-986393
  • Alnuctamab
  • Mezigdomide
  • Iberdomide
  • Elranatamab

Treatment groups

147 Participants
are divided into 4 treatment groups