A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-70
SponsorPeking University Cancer Hospital & Institute

About this trial

This study was a phase IB, single-center, open-label, two part(part A involved dose reduction, and part B involved cohort expansion) clinical trial evaluating the safety and clinical activity of AK104 or AK112 in combination with axitinib in patients with advanced mucosal melanoma.

Eligibility criteria

Qualifiers

None

Disqualifiers

Prior treatment with anti-PD-1/PD-L1/PD-L2 antibody and Axitinib

Is currently participating in a study of an investigational agent or using an investigational device

Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy within 2 years prior to the first dose of study treatment

Has undergone major surgery within 30 days of Study Day 1

Trial design

Treatments tested in this trial

  • AK104+Axitinib
  • AK112+Axitinib

Treatment groups

60 Participants
are divided into 2 treatment groups