This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.
Able and willing to provide a written informed consent.
Blood pressure as defined in the protocol.
Male or female，aged 18 to 55 years (inclusive).
Meet the weight standard.
Known history or current clinically significant disease.
Protocol-defined risk factors for disease.
Participated in clinical trials of other drugs or medical devices.
Pregnant or nursing women.