A Trial of SHR-A1912 Combined With Other Therapies in B-cell Non-Hodgkin 's Lymphoma

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorShanghai Hengrui Pharmaceutical Co., Ltd.

About this trial

This study aims to evaluate the safety, PK and preliminary anti-tumour activity of SHR-A1912 combined with other therapies in patients with B-cell non-Hodgkin 's lymphoma.

Eligibility criteria

Qualifiers

Age greater than or equal to18 years old;

Eastern Cooperative Oncology Group (ECOG) performance status is 0 to 1;

Life expectancy >3 months;

Histologically confirmed B-cell B-cell non-Hodgkin's lymphoma;

Disqualifiers

Received autologous stem cell transplantation within 12 weeks before the first study treatment; previously received allogeneic stem cell transplantation; received Car-T cell therapy within 12 weeks before the first study treatment;

History of recent major surgery or severe trauma within 4 weeks before the first study treatment;

Received anti-tumour treatment within 2 weeks before the first study treatment;

Central nervous system (CNS) infiltration;

Trial design

Treatments tested in this trial

  • SHR-A1912; R-Chemo
  • SHR-A1912; R-Chemo

Treatment groups

132 Participants
are divided into 2 treatment groups