The study is being conducted to evaluate the safety, tolerability and efficacy of SHR-A2102 for injection with Antitumor Therapy in Advanced Urothelial Carcinoma. To explore the reasonable dosage of SHR-A2102 for Advanced Urothelial Carcinoma.
Competent to comprehend, sign, and date an informed consent form.
Male or female subjects must be age 18 or older.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Subjects must have histologically documented, unresectable locally advanced or
Subjects with not adequately treated, or uncontrollable , or active CNS metastases.
Subjects who have previously received TOPO1-based ADCs.
Subjects who have received anti-cancer treatment within 4 weeks prior the first dose of study treatment.
Subjects who have received radiotherapy within 14 days , or chest radiotherapy > 30Gy within 6 months prior to the first dose of study drug.