Health Trials

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome

ConditionsShort Bowel SyndromeInfection, Bacterial
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentral Hospital, Nancy, France

About this trial

The purpose of this study is to assess the drug absorption of oral antibiotics in patients with short bowel syndrome.

Eligibility criteria

Qualifiers

Short bowel syndrome

Treated for a documented infection with antibiogram by amoxicillin (+/- clavulanic acid)or ofloxacin or levofloxacin or sulfamethoxazole/trimethoprim

Hospitalized in the Nutritional Assistant Unit or the Infectiology Unit of the Regional University Hospital of Nancy

Affiliated to a social security system

Disqualifiers

Patient at risk of worsening their oral absorption abilities during study

Patient requiring dialysis

Women of childbearing age without efficient birth control

Allergy to any of the drugs tested

Trial design

Treatments tested in this trial

  • Amoxicillin
  • Levofloxacin
  • Ofloxacin
  • Sulfamethoxazole trimethoprim

Treatment groups

10 Participants
are divided into 4 treatment groups

Sponsors and collaborators

Central Hospital, Nancy, France

Lead sponsor

Société Francophone Nutrition Clinique et Métabolisme

Collaborator

FIlière des Maladies rares Abdomino-THOraciques

Collaborator

Fresenius Kabi

Collaborator

Source ClinicalTrials.gov