This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); and (3) "accelerated" rTMS over the left dorsolateral prefrontal cortex, by examining standardized repeated measures of clinical outcomes at baseline, during treatment, and at 4-, 12-, 24- and 52-week follow-up.
Taking benzodiazepines with opioids
Substance Use Disorder diagnosis [non-tobacco; Opioid Risk Tool]
Dizziness and/or falls
Difficult-to-manage stomach pain, nausea, constipation or GI issues
. Those with nicotine use disorder.
. Those meeting criteria for prescription opioid use disorder using only prescribed opioids will be considered on a case-by-case basis.
Medical University of South Carolina
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator