About this trial
This protocol aims to evaluate how NMT affects pediatric nasal microbiome diversity following intranasal mupirocin treatment
Eligibility criteria
Qualifiers
Child has had a prior nasal surveillance culture grow S. aurues
Child is <18 years of age
Child completed treatment with intranasal mupirocin for S. aureus nasal colonization as part of routine clinical care two or more days before the planned transplant
Child has anticipated hospital length of stay >3 days after completing intranasal mupirocin treatment
Disqualifiers
Child is a ward of the State
Child with a diagnosis of immunodeficiency or antenatal suspicion for immunodeficiency (e.g., sibling with known immunodeficiency, genetic syndrome with known associated immunodeficiency)
Child cannot have nasal swabs collected (due to anatomic or other clinical intervention, including nasal packing)
Donor is able to provide informed consent
Trial design
Treatments tested in this trial
- Nasal Microbiota Transplant (NMT)
- Placebo