Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age0-60
SponsorJohns Hopkins University

About this trial

This protocol aims to evaluate how NMT affects pediatric nasal microbiome diversity following intranasal mupirocin treatment

Eligibility criteria

Qualifiers

Child has had a prior nasal surveillance culture grow S. aurues

Child is <18 years of age

Child completed treatment with intranasal mupirocin for S. aureus nasal colonization as part of routine clinical care two or more days before the planned transplant

Child has anticipated hospital length of stay >3 days after completing intranasal mupirocin treatment

Disqualifiers

Child is a ward of the State

Child with a diagnosis of immunodeficiency or antenatal suspicion for immunodeficiency (e.g., sibling with known immunodeficiency, genetic syndrome with known associated immunodeficiency)

Child cannot have nasal swabs collected (due to anatomic or other clinical intervention, including nasal packing)

Donor is able to provide informed consent

Trial design

Treatments tested in this trial

  • Nasal Microbiota Transplant (NMT)
  • Placebo

Treatment groups

175 Participants
are divided into 3 treatment groups

Sponsors and collaborators