Applying pGz in Mitochondrial Disease
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age10-60
SponsorChildren's Hospital of Philadelphia
About this trial
This is a multi-aim study, studying the effects of conventional exercise (measured through Cardiopulomary Exercises Testing or an in-bed pedal exercise) and passive exercise through periodic acceleration (pGz). Aim 1 will focus on the differences between primary mitochondrial disease (PMD) patients and healthy volunteers. Aim 2 is an exploratory aim, which will be studying the effects in patients admitted to the Children's Hospital of Philadelphia Pediatric Intensive Care Unit (PICU).
Eligibility criteria
Qualifiers
Males or females, 10 years to 60 years, with a minimum height for participation of 135 cm
Ambulatory and able to complete routine clinical exercise testing
Willing and able to complete all study procedures
For individuals under the age of 18, parental/guardian permission (informed consent) and as appropriate, child assent
Disqualifiers
Tracheostomy
Non-ambulatory
Unable to complete routine exercise testing
Diagnosed with or have symptoms of vertigo
Trial design
Treatments tested in this trial
- Cardiopulmonary Exercise Testing
- pGz Bed
- Gentle Jogger
- Exercise Pedal
- Lumason® contrast agent
Treatment groups
90 Participants
are divided into 3 treatment groupsSponsors and collaborators
Children's Hospital of Philadelphia
Lead sponsor
United States Department of Defense
Collaborator
Source ClinicalTrials.gov