This is an open-label, multi-center Phase 1b clinical study of oral AS-1763 (docirbrutinib) in patients with CLL/SLL or B-cell NHL who have failed or are intolerant to ≥2 lines of systemic therapy.
Age ≥18 years
Provided written informed consent
Histologically confirmed B-cell malignancy, including CLL/SLL, WM, MCL, MZL, or FL
Patients with SLL, MCL, MZL, and FL: at least 1 radiographically measurable lesion
Transformed disease (eg, Richter's transformation) prior to or during Screening
Investigational agent or anticancer therapy within 5 half-lives before the planned start of docirbrutinib, except therapeutic monoclonal antibody treatment which must be discontinued at least 4 weeks before the start of docirbrutinib
Current treatment with investigational therapy or planned investigational therapy which would be concurrent with this study
Requiring therapeutic anticoagulation with warfarin