Current guidelines mandate Helicobacter pylori (H. Pylori) eradication with 2-3 antibiotics for 14 days ,This may result in multiple side effects and in eradication of important bacterial species to human health, exposing humans to multiple disease conditions.
Preservation of fecal microbiome prior to antibiotic therapy and auto-transplantation of the microbes post H. pylori eradication, will enable avoiding eradication of beneficial microbial populations and perhaps protect from consequent disease conditions.
Age 18-70 years old
Positive H. pylori on either breath test or gastric biopsy
Patient is intended to receive antibiotics therapy for H. pylori eradication
Severe systemic disease that may impact the microbiome. For example: heart disease, type two diabetes, chronic liver or kidney failure
Antibiotics therapy during the prior 2 months to enrollment
Planned to receive antibiotics within the upcoming 2 months (surgery etc) for reasons other than H. Pylori
Inability to complete the study protocol (swallow capsules or to hold enema content for at least 15 minutes)
Tel-Aviv Sourasky Medical Center
Lead sponsor
Weizmann Institute of Science
Collaborator