Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection

Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexFemale
AgeNot listed
SponsorUniversity of Calgary

About this trial

This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip. The patient has exhausted all conventional therapies, both surgical and medical, at considerable detriment to their quality of life. The treatment involves 2 intra-articular injections of bacteriophages into the joint and surrounding area and 14 days of intravenous phage therapy. The goal is to eliminate the infection and prevent further complications, providing a potential new treatment avenue for patients with difficult-to-treat infections.

Eligibility criteria

Qualifiers

Diagnosis of active chronic prosthetic joint infection

Causative bacteria is susceptible to bacteriophage therapy in vitro

History of multiple failed antibiotic and surgical interventions

Disqualifiers

Stage 5 chronic kidney disease

Cirrhosis

A known allergy to phage products

Fever

Trial design

Treatments tested in this trial

  • Five phage anti-Staphylococcus aureus bacteriophage cocktail

Treatment groups

1 Participants
are divided into 1 treatment group

Sponsors and collaborators

University of Calgary

Lead sponsor

Qeen Biotechnologies

Collaborator