About this trial
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip. The patient has exhausted all conventional therapies, both surgical and medical, at considerable detriment to their quality of life. The treatment involves 2 intra-articular injections of bacteriophages into the joint and surrounding area and 14 days of intravenous phage therapy. The goal is to eliminate the infection and prevent further complications, providing a potential new treatment avenue for patients with difficult-to-treat infections.
Eligibility criteria
Qualifiers
Diagnosis of active chronic prosthetic joint infection
Causative bacteria is susceptible to bacteriophage therapy in vitro
History of multiple failed antibiotic and surgical interventions
Disqualifiers
Stage 5 chronic kidney disease
Cirrhosis
A known allergy to phage products
Fever
Trial design
Treatments tested in this trial
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
Treatment groups
Sponsors and collaborators
University of Calgary
Lead sponsor
Qeen Biotechnologies
Collaborator