The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish this, the investigators propose obtaining image-guided measures of tissue pH and biopsied tissue in tumor areas selected for bulk resection surgery. Investigators will then correlate the imaging measurements with pH, RNA expression, protein expression, and bioenergetics measurements of key glycolytic enzymes.
Age > 18
Patients with newly diagnosed or recurrent glioblastoma clinically indicated for resective surgery
Patients who cannot obtain an MRI or FDG PET scan with contrast
Those with ferromagnetic implanted devices that might produce a safety hazard (e.g. infusion pumps, pace makers, aneurysm clips, etc.) will be excluded from the study along with subjects with severe claustrophobia or who have severely compromised renal function (GFR < 30).
Jonsson Comprehensive Cancer Center
Lead sponsor
National Center for Advancing Translational Sciences (NCATS)
Collaborator