Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
ConditionFracture
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age65+
SponsorThe Cooper Health System
About this trial
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are:
Is buprenorphine as effective as opioids to treat pain? Are there less side effects with buprenorphine? Researchers will compare buprenorphine and hydromorphone to see if there are differences in pain control and side effects.
Participants will be given one of the two study drugs after breaking a bone and asked about their pain scores and side effects for the next 48 hours.
Eligibility criteria
Qualifiers
Age 65 years or older
Emergency Department patient
Diagnosis of suspected or confirmed acute fracture
Numerical Rating Scale 4 or greater at time of presentation
Disqualifiers
Prior history of opioid use disorder
Participants taking chronic opioid therapy (defined as opioids taken during the past month)
Allergy to study medications
Hemodynamic instability requiring immediate resuscitation
Trial design
Treatments tested in this trial
- Buprenorphine 0.15 MG
- Hydromorphone 0.25 mg IV
Treatment groups
48 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov