CAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases
Age ≥ 18 years old (inclusive), regardless of gender.
Positive expression of CD19 or BCMA on peripheral blood B cells confirmed by flow cytometry.
Functional requirements for major organs are as follows（Except for abnormalities related to autoimmune disease activity）: 1) Bone marrow function must meet: A. Neutrophil count ≥ 1×109/L (no colony-stimulating factor treatment within 2 weeks before examination); B. Hemoglobin ≥ 60g/L; 2) Liver function: Alanine aminotransferase (ALT) ≤ 3×ULN (excluding ALT elevation due to inflammatory myopathy), aspartate aminotransferase (AST)≤3×Upper limit of normal (ULN) (excluding AST elevation due to inflammatory myopathy), TBIL≤2×ULN (or ≤ 3.0×ULN for subjects with Gilbert syndrome); 3) Renal function: creatinine clearance rate (CrCl) ≥ 30ml/minute (calculated by Cockcroft/Gault formula, acute CrCl decrease due to the target disease is excluded; LN is exluded).
ECOG score 0-2.
Subjects with a history of severe drug allergies or allergic tendencies.
Presence or suspicion of uncontrolled or treatment-required fungal, bacterial, viral, or other infections.
Subjects with central nervous system diseases caused by autoimmune diseases or non-autoimmune diseases (including epilepsy, psychosis, organic brain syndrome, cerebral vascular accidents, encephalitis, central nervous system vasculitis).
Subjects with insufficient cardiac function.
Institute of Hematology & Blood Diseases Hospital, China
Lead sponsor
Shanghai Xiniao Biotech Co., Ltd.
Collaborator