CAR-T Cells Targeting Autoimmune Diseases
ConditionAutoimmune Diseases
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShenzhen Geno-Immune Medical Institute
About this trial
The purpose of this study is to assess the feasibility, safety and efficacy of CAR-T cell therapy in patients with autoimmune disease. Another goal of the study is to learn more about the safety and function of the CAR-T cells and their persistency in autoimmune disease patients.
Eligibility criteria
Qualifiers
age older than 18 years.
expression of B cell surface molecules.
the KPS score over 80 points, and survival time is more than 3 months.
greater than Hgb 80 g/L.
Disqualifiers
accompanied with other active diseases and difficult to assess treatment response.
bacterial, fungal, or viral infection, unable to control.
living with HIV.
active HBV or HCV infection.
Trial design
Treatments tested in this trial
- 4SCAR T cells
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov