Health Trials

Chronic Lung Allograft Dysfunction MRI Study

ConditionChronic Lung Allograft Dysfunction Lung MRI (CLAD)
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorSean Fain

About this trial

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Eligibility criteria

Qualifiers

Ages 18-80

English Speaking Subjects

Willingness and ability to provide informed consent

Non-smoker

Disqualifiers

SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing

Unilateral diaphragm paralysis

Evidence of acute illness on day of study

Evidence of restrictive lung disease

Trial design

Treatments tested in this trial

  • Spirometry
  • Contrast Lung Computed Tomography (CT) Scan
  • Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan
  • 129Xe MRI scans

Treatment groups

100 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Sean Fain

Lead sponsor

University of Iowa

Sponsor institution

Source ClinicalTrials.gov