Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorART Fertility Clinics LLC
About this trial
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
Eligibility criteria
Qualifiers
Age: 18 to 40 years
Regular ovulatory cycles
Availability of at least one euploid embryo after Trophectoderm biopsy for PGT-A on day 5 or day 6
Detection of ovulation by P4 rise > 1.0 ng/ml after LH surge
Disqualifiers
History of repeated pre-menstrual spotting
Factors affecting the implantation through anatomical changes of the uterus / ovaries or the tubes (adenomyosis, Asherman syndrome, endometriosis, uterine fibroids / polyps, isthmocele with intracavitary fluid presence, hydrosalpinx….)
Trial design
Treatments tested in this trial
- Transvaginal ultrasound
- Serial serum LH, E2, P4
- Progesterone 100 Mg Vaginal Insert
- Serum P4 day of ET - Control Group
- Serum P4 day of ET - Study Group
- Embryo transfer
- Serum hCG 10 days after ET
- Serum P4 10 days after ET
Treatment groups
342 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov