Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversidade Federal do Para

About this trial

The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.

Eligibility criteria

Qualifiers

Participants must have at least 28 teeth in the cavity

Good oral and general health

Disqualifiers

active caries or periodontal disease

visible cracks in front teeth upper or lower

with evident malocclusion

restorations and prosthetics in teeth anterior teeth

Trial design

Treatments tested in this trial

  • Potassium nitrate and sodium fluoride
  • Cannabidiol (CBD) Gel
  • Natrosol 4% Gel

Treatment groups

75 Participants
are divided into 3 treatment groups

Sponsors and collaborators