Health TrialsbyHealthPanel

Effect of GnRH Agonist in FET

ConditionGnRH Agonist
Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexFemale
Age20-39
SponsorAssiut University

About this trial

To evaluate the impact of single dose GnRH agonist administration as luteal phase support on pregnancy outcomes in frozen ICSI cycle

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

1. Age 20-39 years 2. Undergoing HRT-FET cycle 3. ≥1 good quality embryo available , Gardner ≥3BB 4. Endometrial thickness ≥7mm on day of progesterone start 5. BMI 18-35 kg/m² 6. First or second FET cycle 7. Written informed consent

Disqualifiers

1. History of recurrent implantation failure ≥3 failed embryo transfers 2. Severe endometriosis Stage III-IV by ASRM 3. Uterine anomalies, submucous fibroid, or severe adenomyosis distorting cavity 4. History of recurrent pregnancy loss ≥2 consecutive 5. Contraindication or hypersensitivity to GnRH agonist 6. PGT-A cycles 7. Donor oocyte cycles

Trial design

Design model

Parallel

Treatments tested in this trial

  • GnRH agonist

    Drug

    women undergoing frozen ICSI cycles receiving progesterone + GnRH agonist for luteal phase support.

Treatment groups

122 Participants
are divided into 2 treatment groups
Group A: Standard HRT protocol only. No additional injectionNo intervention 0 interventions
Group B: Standard HRT protocol + Triptorelin 0.1mg subcutaneous injection, administered once 30-60 minutes afExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Clinical pregnancy rate

Presence of ≥1 gestational sac with fetal heartbeat on TVS at 6-7 weeks per embryo transfer.

Time frame
basline

Secondary outcomes

1

Implantation rate

Number of gestational sacs / Number of embryos transferred x100

Time frame
basline
2

Ongoing pregnancy rate

Viable pregnancy ≥12 weeks gestation per ET

Time frame
basline
3

Early miscarriage rate

Pregnancy loss \<12 weeks after clinical pregnancy diagnosed

Time frame
basline
4

. Live birth rate per ET

. Live birth rate per ET

Time frame
basline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Woman's Health University Hospital, Egypt

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: