Effects of Neostigmine-dose on Diaphragmatic Dynamics
ConditionDiaphragm Ultrasound
Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-75
SponsorAswan University Hospital
About this trial
The goal of this Randomized Clinical Trial is to compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg/kg) and those receiving full-dose neostigmine (0.08 mg/kg) for neuromuscular blockade reversal.
The main questions it aims to answer are:
* Does half-dose neostigmine result in similar postoperative diaphragmatic excursion compared to full-dose neostigmine? * Does half-dose neostigmine result in similar diaphragmatic thickening fraction compared to full-dose neostigmine? Researchers will compare patients receiving half-dose neostigmine to those receiving full-dose neostigmine to see if there are differences in postoperative diaphragmatic function, respiratory complications, and recovery.
Participants will:
* Undergo elective laparoscopic cholecystectomy. * Receive either half-dose or full-dose neostigmine for neuromuscular blockade reversal.
Eligibility criteria
Qualifiers
Adults scheduled for elective laparoscopic cholecystectomy.
Age: < or = 18 years.
Both genders.
American Society Of Anesthiologists (ASA) I/II patients.
Disqualifiers
Pre-existing diaphragmatic or respiratory disorders.
ASA III/IV
BMI >35
Chronic opioid use or abuse
Trial design
Treatments tested in this trial
- full dose of Neostigmine
- half dose of Neostigmine
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov