About this trial
This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.
Eligibility criteria
Qualifiers
Healthy volunteers
Normal ECG
Normal Blood Pressure
Normal lipid levels
Disqualifiers
Participants with a history of diabetes mellitus,BP
With chronic diseases e.g heart disease, kidney disease
QTc ≥450 ms (men) or ≥470 ms (women)
ECG changes
Trial design
Treatments tested in this trial
- Rosuvastatin (5mg, 20mg, 40mg)
- Atorvastatin (10mg, 20mg, 40mg)
- Simvastatin (10mg, 20mg, 40m
Treatment groups
Sponsors and collaborators
Shaheed Benazir Bhutto University Sheringal Dir Upper
Lead sponsor
Khyber Medical University Peshawar
Collaborator