[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers]

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-25
SponsorShaheed Benazir Bhutto University Sheringal Dir Upper

About this trial

This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.

Eligibility criteria

Qualifiers

Healthy volunteers

Normal ECG

Normal Blood Pressure

Normal lipid levels

Disqualifiers

Participants with a history of diabetes mellitus,BP

With chronic diseases e.g heart disease, kidney disease

QTc ≥450 ms (men) or ≥470 ms (women)

ECG changes

Trial design

Treatments tested in this trial

  • Rosuvastatin (5mg, 20mg, 40mg)
  • Atorvastatin (10mg, 20mg, 40mg)
  • Simvastatin (10mg, 20mg, 40m

Treatment groups

100 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Shaheed Benazir Bhutto University Sheringal Dir Upper

Lead sponsor

Khyber Medical University Peshawar

Collaborator