Effort and Antidepressant Study Test
Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Oxford
About this trial
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task measuring self-benefiting and prosocial behaviours.
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the research
Aged 18 to 40 years
Sufficient knowledge of English language to understand and complete study tasks
Right-handed
Disqualifiers
Current or past probable diagnosis of psychiatric illness, according to DSM-5 criteria requiring intervention by a healthcare professional, including but not limited to psychosis, bipolar disorder, major depression, OCD, PTSD, substance abuse disorder or any eating disorder
Current or past diagnosis of any significant personality disorder (e.g., borderline personality disorder) according to self-report
Diagnosis of attention deficit hyperactive disorder or autistic spectrum disorder that impairs daily functioning, requires pharmacotherapy or in the opinion of the study medic would affect the scientific integrity of the study
Current use of medication that might interact with the effects of escitalopram or affect the scientific integrity of the study
Trial design
Treatments tested in this trial
- Escitalopram 10mg
- Placebo 10 mg
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
University of Oxford
Lead sponsor
Wellcome Trust
Collaborator
Source ClinicalTrials.gov