The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as an autologous bone-regenerating graft in the reconstruction of deficient bone in two clinical indications:
1. Long and short bone extra-articular comminuted fracture 2. Long and short bones extra and intra articular defect /Gap or non-union, incapable of self-regeneration
Long and short bones extra articular comminuted fracture or
Long and short bones extra and intra articular defect/gap or non union, incapable of self-regeneration
Age is under 18 or above 80
A simple fracture manageable by one definitive treatment
Pregnant or lactating women
Patients with active infection that is in question and needs osteogenic treatment.