it is a randomized control trial and aims at investigating the effects of PRF on rate of tooth movement and root length to be tested on larger sample size of pakistani population
Patients who give written consent to participate in the research
Orthodontic patients with good oral hygiene
Patients with periodontal probing depths≤3 mm with no bone loss
Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction
patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded.