Exploratory Clinical Study on the Safety and Efficacy of CD19X CAR-T Cell Injection in the Treatment of Relapsed/Refractory Large B-Cell Lymphoma

Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorInstitute of Hematology & Blood Diseases Hospital, China

About this trial

This study is an open-label, single-arm, prospective, exploratory clinical trial involving patients with relapsed/refractory large B-cell lymphoma, aiming to preliminarily assess the safety and efficacy of CAR-T cell infusion.

Eligibility criteria

Qualifiers

1. The participant has given consent and signed the informed consent form, and is willing and able to comply with planned visits, research treatments, laboratory tests, and other trial procedures;

Anti-CD20 monoclonal antibody;

Combination chemotherapy containing anthracyclines.

3. Age 18 years and above, both male and female;

Disqualifiers

1. Severe heart failure with left ventricular ejection fraction <50%;

2. History of severe pulmonary dysfunction;

3. Concurrent progressive malignant tumors;

4. Severe infections that cannot be effectively controlled;

Trial design

Treatments tested in this trial

  • CD19X CAR-T

Treatment groups

3 Participants
are divided into 1 treatment group

Locations

This trial has no locations