Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
diagnosis of PCOS
overweight-obese (BMI >25 kg/m2)
elevated fasting plasma TG (>150 mg/dL)
and/or apoB48-remnant cholesterol lipoproteins (>20 ug/ml)
None
University of Alberta
Lead sponsor
Heart and Stroke Foundation of Canada
Collaborator