About this trial
FT-003 is a gene therapy product developed for the treatment of neovascular age-related macular degeneration (nAMD). Neovascular AMD is the main cause of blindness among elderly individuals. The available therapies for treating nAMD require life-long intravitreal (IVT) injections every 4-12 weeks to maintain efficacy. Administration of FT-003 has the potential to treat nAMD by providing durable expression of therapeutic levels of intraocular protein and maintaining the vision of patients. FT-003 is designed to reduce the current treatment burden which often results in undertreatment and vision loss in patients with nAMD receiving anti-VEGF therapy in clinical practice.
Eligibility criteria
Qualifiers
Subjects that are willing and able to follow study procedures;
Female or male patients ≥45 years old at the time of signing the ICF;
Clinically diagnosed with nAMD;
Presence of active CNV
Disqualifiers
None
Trial design
Treatments tested in this trial
- FT-003
Treatment groups
Locations
Sponsors and collaborators
Frontera Therapeutics
Lead sponsor
The First Affiliated Hospital of Soochow University
Collaborator
Tianjin Medical University Eye Hospital
Collaborator
Peking Union Medical College Hospital
Collaborator
The First Affiliated Hospital of Zhengzhou University
Collaborator