Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorSun Yat-sen University

About this trial

This is a prospective, multicenter, open-label, phase Ib/II clinical study to evaluate the safety and efficacy of golidocitinib combined with mitoxantrone hydrochloride liposome or chidamide in the treatment of relapsed or refractory peripheral T-cell lymphoma

Eligibility criteria

Qualifiers

Voluntarily participate in the clinical study; fully understand and be informed about the study and sign the Informed Consent Form (ICF); willing to comply with and capable of completing all trial procedures;

Diagnosed with PTCL according to the 2022 revised WHO lymphoma classification standards based on pathological diagnosis by the research center

Using the Lugano 2014 lymphoma efficacy evaluation criteria, the patient must have at least one measurable or evaluable lesion

Age ≥ 18 years

Disqualifiers

Accompanied by hemophagocytic lymphohistiocytosis (HLH)

Lymphoma involvement in the central nervous system or meninges

Active infections

Uncontrolled clinical cardiac symptoms or diseases

Trial design

Treatments tested in this trial

  • Golidocitinib
  • Mitoxantrone Hydrochloride Liposome
  • Chidamide

Treatment groups

101 Participants
are divided into 1 treatment group

Sponsors and collaborators