Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
ConditionPost-Traumatic Headache
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorYale University
About this trial
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.
Eligibility criteria
Qualifiers
United States Military Veterans within VA Connecticut Healthcare System
Chronic post-traumatic headache per ICHD-3 criteria (i.e., headaches are continuing to occur three months after the head injury)
At least two headache days per week
MRI brain scan completed within the past 3 months if chronic PTH for less than one year, within the past year if chronic PTH for less than 5 years, and within 5 years if chronic PTH for more than 10 years
Disqualifiers
Skull defect
Other contraindication to bupivacaine
Allergy or adverse reaction (e.g., rash, cardiac effects) to amide anesthetics, such as lidocaine
Instruction from clinician to avoid amide anesthetics, such as lidocaine
Trial design
Treatments tested in this trial
- Bupivacaine Injection
Treatment groups
12 Participants
are divided into 4 treatment groupsSponsors and collaborators
Yale University
Lead sponsor
VA Connecticut Healthcare System
Collaborator
National Headache Foundation
Collaborator
Source ClinicalTrials.gov