The goal of this clinical trial is to find out if taking natural products green tea and quercetin along with docetaxel chemotherapy improves the therapy of advanced prostate cancer, i.e., metastatic castration-resistant prostate cancer (mCRPC). It will also learn about the safety of this combination.
Researchers will compare green tea plus quercetin to a placebo (a look-alike substance that contains no drug) in combination with docetaxel to see if green tea and quercetin works to improve the therapeutic effect of docetaxel.
Signed and dated informed consent form and HIPPA (Health Insurance Portability and Accountability Act) authorization.
Stated willingness to comply with all study procedures and availability for the duration of the study.
Male patients 18 years or older
Diagnosed with metastatic prostate cancer
Prior treatment of chemotherapy and/or radiotherapy for metastatic disease
Any comorbid condition that would preclude the administration of docetaxel/prednisone
Ongoing alcohol abuse
Significant medical or psychiatric conditions that would make the patient a poor protocol candidate
Charles Drew University of Medicine and Science
Lead sponsor
National Institute on Minority Health and Health Disparities (NIMHD)
Collaborator
Watts Healthcare Corporation
Collaborator