Hydroxychloroquine Sulfate Tablets for Radiation-induced Oral Mucositis
ConditionRadiation-induced Oral Mucositis
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorXingchen Peng
About this trial
Evaluate the safety, tolerance and efficacy of hydroxychloroquine sulfate tablets the prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy
Eligibility criteria
Qualifiers
Patients pathologically diagnosed with non-metastatic head and neck malignant tumors
Aged 18-80 years
Eastern Cooperative Oncology Group performance status of ≤2
Planning to receive definitive RT or postoperative adjuvant RT
Disqualifiers
Those who are known to be allergic to 4-aminoquinoline compounds or have more serious allergic constitution
Had a history of head and neck radiotherapy
Patients with non head and neck parts in the radiotherapy area
Poor oral hygiene or severe periodontitis
Trial design
Treatments tested in this trial
- Hydroxychloroquine Sulfate Tablets
- Placebo
Treatment groups
158 Participants
are divided into 2 treatment groupsSponsors and collaborators
Xingchen Peng
Lead sponsor
West China Hospital
Sponsor institution
Source ClinicalTrials.gov