Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

ConditionsAsthma COPD Interstitial Lung Disease Cystic Fibrosis Pulmonary Hypertension Pulmonary Infection Other Lung Disease

Trial statusRecruiting

Trial phasePhase 1

Trial typeInterventional

Biological sexAll

Age3+

SponsorMario Castro, MD, MPH

About this trial

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Eligibility criteria

Qualifiers

Subject has no diagnosed pulmonary conditions

Ability to read and understand English or Spanish

Subject has a diagnosis of pulmonary dysfunction made by a physician

No acute worsening of pulmonary function in the past 30 days

Disqualifiers

MRI is contraindicated based on responses to MRI screening questionnaire

Subject is pregnant or lactating

Subject does not fit into 129Xe vest coil used for MRI

Subject cannot hold his/her breath for 15-16 seconds

Trial design

Treatments tested in this trial

Hyperpolarized Xe129

Treatment groups

260 Participants

are divided into 1 treatment group

Sponsors and collaborators

Mario Castro, MD, MPH

Lead sponsor

University of Kansas Medical Center

Sponsor institution

Source ClinicalTrials.gov