Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Pennsylvania
About this trial
The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imaging drug that is labeled with a radioactive tag and injected into the body.
Eligibility criteria
Qualifiers
Participants will be 18-45 years of age
Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.
Disqualifiers
Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; a urine pregnancy test will be performed in women of child-bearing potential at screening and on scan day.
Current untreated and unstable diagnosis of substance use disorder, except nicotine use disorder or cannabis use disorder
Positive urine drug screen for opiates, methamphetamine or cocaine at screening
Current unstable and/or untreated major depression or psychotic disorder per medical record review or self-reported
Trial design
Treatments tested in this trial
- [18F]NOS
Treatment groups
100 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Source ClinicalTrials.gov