Individualized Tumor Specific TCR- T Cells in the Treatment of Advanced Solid Tumors

ConditionSolid Tumor
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-70
SponsorGuangzhou FineImmune Biotechnology Co., LTD.

About this trial

The primary purpose of this study is to evaluate the safety of the tumor-specific TCR-T cells in the treatment of advanced Solid Tumor .

The secondary purpose of this study is to preliminarily showed the effect of TCR-T cells in the treatment of advanced Solid Tumor .

Eligibility criteria

Qualifiers

Aged between 18 and 70 years old, regardless of gender;

Diagnosed as solid tumors by histopathology, and the tumor lesions could be detected or evaluated;

Be after standard treatment or who lack effective treatment programs;

Patients and their families were willing to participate in the clinical trial and signed the informed consent;

Disqualifiers

Any form of primary immunodeficiency disease (such as severe combined immunodeficiency disease);

Experiencing moderate to severe infection or possible opportunistic infection;

Patients with a history of autoimmunity (e.g., SLE, psoriasis, etc.);

Acute systemic infection, coagulation dysfunction or other serious cardiopulmonary diseases;

Trial design

Treatments tested in this trial

  • tumor-specific TCR-T cells
  • Interleukin-2

Treatment groups

30 Participants
are divided into 1 treatment group

Sponsors and collaborators

Guangzhou FineImmune Biotechnology Co., LTD.

Lead sponsor

Sun Yat-Sen University Cancer Center

Collaborator