Influenza Human Challenge Model
ConditionInfluenza
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-49
SponsorEmory University
About this trial
This study examines how the immune system responds to the flu virus (H3N2) during and after infection and how the flu virus is transmitted in the environment. The study will used a flu virus called the H3N2 influenza challenge virus which was produced specifically for use in clinical research in controlled conditions. The study will also assess the safety of the H3N2 influenza challenge in healthy subjects. Mild to moderate symptoms are expected based on previous studies with this strain of influenza.
Eligibility criteria
Qualifiers
Provide written informed consent prior to initiation of any study procedures.
Are able to understand and comply with all planned study procedures.
Healthy males and non-pregnant, non-breast-feeding females aged ≥18 and ≤49 years of age inclusive at enrollment.
Women of childbearing potential must be practicing abstinence or using an acceptable method of birth control for at least 30 days prior to enrollment through the duration of the trial. Male subjects must agree not to father a child for the duration of the trial.
Disqualifiers
Children under 5 years of age
Children and/or teenagers who are receiving long-term aspirin therapy
Women who are pregnant or who are trying to become pregnant
Persons older than 65 years of age
Trial design
Treatments tested in this trial
- Influenza Virus Type A H3N2 Challenge
Treatment groups
80 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov