Low Dose Radiotherapy for Heart Failure
ConditionHeart Failure - NYHA II - IV
Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorHospital do Coracao
About this trial
The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.
Eligibility criteria
Qualifiers
Age >18 years;
Clinical and laboratory diagnosis of chronic systolic HF grades II or III of the New York Heart Association with ejection fraction <40%;
Refractoriness to standard clinical treatment; defined as the persistence of HF signs and symptoms despite optimized drug therapy.
Patient consent to participate in the study.
Disqualifiers
Patients who have undergone any type of previous radiotherapy in the thoracic region;
Patients who have undergone heart transplants;
Contraindications for magnetic resonance imaging (MRI), such as the use of metal implants or prostheses.
Pregnant patients.
Trial design
Treatments tested in this trial
- Radiation Therapy
Treatment groups
10 Participants
are divided into 1 treatment groupSponsors and collaborators
Hospital do Coracao
Lead sponsor
Financiadora de Estudos e Projetos
Collaborator
Source ClinicalTrials.gov