Managing Chronic Tendon Pain by Metformin
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-50
SponsorJames Wang
About this trial
The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be treated with placebo tablets along with home exercise program.
Eligibility criteria
Qualifiers
Willing and able to provide informed consent for participation
Clinical diagnosis of Achilles tendinopathy
Pain disability index score of between 20 - 70 points (0-100 scale VISA-A)
Sonopalpation tenderness with tendon thickening and/or loss of fibrillary architecture.
Disqualifiers
Any intervention (corticosteroids or other orthobiologic intervention as injection) to targeted tissue within the last 6 months.
Previous Achilles tendon surgery.
Known platelet abnormality or hematological disorder.
Presence of other conditions that might affect the functional scale of the indexed limb.
Trial design
Treatments tested in this trial
- Metformin
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
James Wang
Lead sponsor
University of Pittsburgh
Sponsor institution
United States Department of Defense
Collaborator
Source ClinicalTrials.gov