The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.
Planned primary total knee arthroplasty of a single knee;
Male or female ≥ 18 years of age;
Capacity to personally give informed consent (consent via legally authorized representative will not be accepted) and who are willing to comply with all study-related procedures and assessments.
Breastfeeding, pregnant, or planning to become pregnant during participation in the study;
Diagnosed with inflammatory or other arthritis caused by autoimmune disease affecting the study knee;
Previous knee arthroplasty on the study knee;
Previous infection affecting the study knee;