Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity of Lausanne Hospitals
About this trial
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology.
Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.
Eligibility criteria
Qualifiers
age <= 85 years
Karnofsky >= 80%
patient with indication ofr carotid endarterectomy
signed consent form
Disqualifiers
indication for surgery other than endarterectomy <14 days
contraindication to surgery
contraindication to MRI
contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR<30ml/min/1.73m2)
Trial design
Treatments tested in this trial
- 68Ga-NODAGA-RGD PET/CT
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Lausanne Hospitals
Lead sponsor
Swiss Heart Foundation
Collaborator
Source ClinicalTrials.gov