Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorNational Jewish Health
About this trial
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
Eligibility criteria
Qualifiers
Participants will have asthma diagnosed by a health care provider. Healthy controls are individuals without asthma.
Written informed consent
Disqualifiers
Current or recent illness (in the past 4 weeks)
Recent asthma exacerbation (past 4 weeks)
History of nasal perforation or nasal surgery
Nasal polyposis
Trial design
Treatments tested in this trial
- Lipopolysaccharides
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov