About this trial
To evaluate pain relief from corticosteroid injection with and without anesthetic as well as with variable volume of anesthetic. Pain relief will be measured using the VAS pain score at the time of the injection as well as several time points following the injection to capture pain relief longevity. The investigators intend to evaluate how well the patients tolerate corticosteroid mixtures without anesthetic as well as with different volumes of anesthetic. Primary measure will be the time from procedure when postoperative status is considered success (as measured by global perceived improvement score).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients must be 18 years of age and be able to consent for themselves.
OA grade Kellgren Lawrence Stage II or III.
Diagnosis of primary osteoarthritis.
Disqualifiers
Patients with other forms of arthritis such as inflammatory arthritis.
History of narcotic use for the past 6 months.
Kellgren Lawrence arthritis grade 1 or 4.
Pregnant women and prisoners.
Trial design
Parallel
Treatments tested in this trial
Kenalog with bupivacaine Injection
DrugIndications, relevant for this study include Kenalog injection for knee pain from osteoarthritis or inflammatory arthritis. A single injection to a patient who has no known allergies to anesthetic or corticosteroids would be administered during a scheduled clinical visit.
Treatment groups
Trial outcomes
Primary outcomes
Injection for Knee Pain
Visual Analogue Scale (VAS)
Injection for Knee Pain
Visual Analogue Scale (VAS)
Injection for Knee Pain
Visual Analogue Scale (VAS)
Injection for Knee Pain
Visual Analogue Scale (VAS)
Secondary outcomes
Assessment of Knee Pain
Global Perceived Improvement
Assessment of Knee Pain
Global Perceived Improvement
Assessment of Knee Pain
Global Perceived Improvement
Assessment of Knee Pain
Global Perceived Improvement
Other outcomes
Medications
Review of Medications
Medications
Review of Medications
Medications
Review of Medications
Medications
Review of Medications
Sponsors and contacts
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Foundation for Orthopaedic Research and Education
Lead sponsor
Florida Orthopaedic Institute
Collaborator