Overcoming Nicotine Dependence to Enable Quitting

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorRush University Medical Center

About this trial

Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly.

One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.

Eligibility criteria

Qualifiers

are 18 years or older

report current daily cigarette smoking (≥ 5 cigarettes per day)

are not planning to quit in the next 30 days

are not currently engaged in smoking cessation treatment

Disqualifiers

are pregnant/breastfeeding

had recent cardiovascular trauma such as myocardial infarction

had a stroke within the past 3 months

Trial design

Treatments tested in this trial

  • Nicotine Replacement Therapy (NRT) Sampling
  • Practice Quitting (PQ) Counseling
  • Motivational Interviewing (MI) Counseling

Treatment groups

780 Participants
are divided into 4 treatment groups

Sponsors and collaborators

Rush University Medical Center

Lead sponsor

Medical University of South Carolina

Collaborator