Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age5-17
SponsorChildren's Mercy Hospital Kansas City

About this trial

This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this is impacted by a person's genetics. Information from this study will also be used to design future clinical trials.

Eligibility criteria

Qualifiers

Ages 5-17 years of age

Diagnosis of cerebral palsy and dystonia causing interference

Parent/legal guardian of a child with a diagnosis of cerebral palsy and dystonia

Parent/legal guardian is willing and able to provide informed permission/assent for the study

Disqualifiers

Previously or currently taking trihexyphenidyl

Patients turning 18 years of age within the study period (16 weeks from Study Day 1)

A language barrier for the patient that precludes communication and/or the ability to complete study-related requirements

Trial design

Treatments tested in this trial

  • Trihexyphenidyl

Treatment groups

40 Participants
are divided into 1 treatment group

Sponsors and collaborators

Children's Mercy Hospital Kansas City

Lead sponsor

University of Kansas Medical Center

Collaborator